Oridonin Extract

bitter taste, micro cold. Have the functions of qingrejiedu, invigorate the circulation of the pain.

For sore throat, tonsillitis, snake insect bites

pharmacologic action

1.Dong ling grass in water or alcohol extract of in vitro cultured hela and esophageal cancer cells have certain cytotoxic effect, also can inhibit the growth of various animal tumor. Dong ling caes17 grass element on human esophageal squamous cancer cells have obvious cytotoxic effect, 2 and 3 mu g/ml concentration, the cell lines

2.Dong, dong ling grass b of oridonin on human liver cancer bel - 7402 cells have a certain role, both kill capability is roughly similar to that of tcd50 4 mu g.The role compared with the effect of urea five fluorine pyrimidine, 2 times the former killing ability is greater than the latter, but from the point of growth curve, winter, of oridoninWinter, b small doses of oridonin, not significantly interfere with cancer cell DNA synthesis. When the dose increase to 8 mu g/ml, 3 h, the mixed - thymidine nucleoside also significantly reduced, that winter, b also has the stop of oridonin bel - 7402 cells to enter s phase or the role of s phase cells

3. The bacteriostatic experiment proves that the dong ling grass for swine, beta hemolytic streptococcus and staphylococcus aureus were inhibition.

4.Clinical trials show that dong ling grass on esophageal and cardia cancer, liver cancer, breast cancer, etc have certain curative effect, make the patients' symptoms, tumors had stable or narrow, prolong patient life; For suppurative tonsillitis, acute and chronic laryngitis, chronic bronchitis, also have good curative effect, etc.

5. Toxicity: dong ling grass to intraperitoneal injection of uterus ld50 was 55.8 + / - 5.7 mg/kg, intraperitoneal injection of rats in dong ling grass, 5 and 10 mg/kg/day. Stay for 10 days to animals had no effect on liver and kidney function and blood picture.